Purified Anti-Human CD178 Antibody[NOK-1], Functional Grade

Fas Ligand (FasL), also known as CD178, CD95L, or TNFSF6, is a transmembrane protein homotrimer that binds to Fas/CD95 and triggers apoptosis in the Fas-expressing cell. Fas Ligand also binds the soluble decoy receptor DcR3. It is expressed on activated Th1 cells, CD8+ cytotoxic T cells, and NK cells. A soluble form can be released which remains trimeric and retains the ability to bind Fas. Fas Ligand-induced apoptosis plays a central role in the development of immune tolerance and the maintance of immune privileged sites. Tumor cells can evade immune surveillance by upregulating Fas Ligand to kill tumor infiltrating lymphocytes. In gld mice, a Fas Ligand point mutation is the cause of severe lymphoproliferation and systemic autoimmunity. None (Azide-Free, Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.

Apoptosis (APO 1) antigen ligand 1; Apoptosis antigen ligand 1; CD95 ligand; CD95L protein; Fas L; Fas ligand (TNF superfamily member 6) ; Fasl Fas ligand (TNF superfamily member 6) ; Generalized lymphoproliferative disease; Gld; soluble form; TNFL6; Tumor necrosis factor (ligand) superfamily member 6; apoptosis (APO-1) antigen ligand; apoptosis (APO-1) antigen ligand; tumor necrosis factor ligand superfamily member; TNFSF; APT1LG; FASLG; ALPS1B; APT1LG1; APTL; CD178; CD95-L; CD95L; FASL; TNFSF6; TNLG1A; Fas ligand; Apo I Ligand; apoptosis (APO-1) antigen ligand 1; Fas ligand (TNF superfamily; member 6) ; soluble Fas Ligand (sFasL) ; APT1LG1CD95L; TNFSF6FasL; apoptosis (APO-1) antigen ligand 1; Apoptosis antigen ligand; CD178 antigen; Fas antigen ligand; FASLCD95 ligand; tumor necrosis factor ligand superfamily member 6; CD95L; TNFSF6

Stem Cells; Immunology; Cell Biology; Cytokine and Growth Factors; Mitochondrial Pathway; Death Receptors Signaling Pathway; CDs; Hematopoietic Stem Cell Markers

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.