Purified Anti-Human CD221 Antibody[1H7]
Selected Variant
AN008870P-01
Size: 25 µg
Product Specifications
Background
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Abbreviation
CD221
Synonyms
JTK; IGF1R; CD221; IGFIR; IGFR; JTK13; CD221 antigen; IGF-1R; IGF-I R; IGF-I receptor; IGF-IR; insulin-like growth factor 1 receptor
UniProt
P08069
Reactivity
Human
Immunogen
Recombinant Human CD221 protein
Clonality
Monoclonal
Clone
1H7
Conjugation
Unconjugated
Applications
FCM
Field of Research
Cancer; Metabolism; Developmental Biology; Neuroscience; Signal Transduction; Cardiovascular Biology; Insulin?Signaling Pathway; Intracellular Kinases; Receptor Tyrosine kinases; Pluripotency Maintenance and Differentiation; AMPK Signaling Pathway; Diabetes; CDs; Angiogenesis; Heart disease; Tumor Biomarkers
Purification Method
>98%, Protein A/G purified
Concentration
≥ 1 mg/mL
Dilution
66
Buffer
Phosphate-buffered solution, pH 7.2, containing 0.05% non-protein stabilizer. Dialyze to completely remove the stabilizer prior to labeling.
Shipping Conditions
Ice bag
Storage Conditions
Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.
Host or Source
Mouse
Control Catalog Number
E-AB-F09793A
Isotype
Mouse IgG1, κ
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