Purified Anti-Mouse CD279 Antibody[RMP1-14], Functional Grade

Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion. None (Azide-Free, Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.

CD279 antigen; hPD 1; hPD l; Ly101; PD 1; Pdc1; PDCD 1; Programmed cell death 1 protein; Protein PD 1; Protein PD-1; Systemic lupus erythematosus susceptibility 2; hPD; mPD; Programmed Death; Programmed cell death; Programmed cell death protein; PDCD; hSLE; SLEB; PD-1; CD279; hPD-1; hPD-l; hSLE1; mPD-1; Programmed cell death 1; Programmed cell death protein 1; Programmed Death-1; SLEB2; Pd1; Pdcd1

Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.