Bacopasaponin C

Bacopasaponin C is an orally active natural glycoside. Bacopasaponin C can be isolated from Bacopa monniera. Bacopasaponin C inhibits Verapamil (HY-14275) -stimulated P-gp ATPase activity with an IC50 of 57.83 μg/mL. Bacopasaponin C has antitumor activity against sarcomas. Bacopasaponin C has antiparasitic activity against Leishmania donovani[1][2][3].

Product Specifications

CAS Number

[178064-13-6]

UNSPSC

12352005

Target

Parasite; P-glycoprotein

Type

Natural Products

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/bacopasaponin-c.html

Purity

99.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]12[C@@]34[C@@](CC[C@]1([H])[C@@]5([C@@](C(C)([C@@H](O[C@@]6([H])[C@@H]([C@H]([C@@H](O)CO6)O[C@]7([H])O[C@@H]([C@@H](O)[C@H](O)[C@H]7O)CO)O[C@]8([H])O[C@@H](CO)[C@H](O)[C@H]8O)CC5)C)([H])CC2)C)([H])[C@]9([H])[C@@](OC4)(OC[C@@H](/C=C(C)\C)[C@@]9(O)C)C3

Molecular Formula

C46H74O17

Molecular Weight

899.07

References & Citations

[1]Peng L, et al. Antitumor activities of dammarane triterpene saponins from Bacopa monniera. Phytother Res. 2010 Jun;24 (6) :864-8.|[2]Sinha J, et al. Bacopasaponin C: critical evaluation of anti-leishmanial properties in various delivery modes. Drug Deliv. 2002 Jan-Mar;9 (1) :55-62.|[3]Singh R, et al. In vitro effects of standardized extract of Bacopa monniera and its five individual active constituents on human P-glycoprotein activity. Xenobiotica. 2015;45 (8) :741-9.