Metronidazole

Metronidazole is an orally active nitroimidazole antibiotic. Metronidazole can cross blood brain barrier. Metronidazole can be used for the research of anaerobic infections[1][2][3][4].

Product Specifications

CAS Number

[443-48-1]

UNSPSC

12352005

Hazard Statement

H340, H350, H373

Target

Antibiotic; Apoptosis; Bacterial; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Metronidazole.html

Purity

99.99

Solubility

DMSO : 35 mg/mL (ultrasonic; warming) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OCCN1C([N+]([O-])=O)=CN=C1C

Molecular Formula

C6H9N3O3

Molecular Weight

171.16

Precautions

H340, H350, H373

References & Citations

[1]Scully BE. Metronidazole. Med Clin North Am. 1988 May;72 (3) :613-21. |[2]Dhurga DB, et al. Granular Formation during Apoptosis in Blastocystis sp. Exposed to Metronidazole (MTZ) . PLoS One. 2016 Jul 29;11 (7) :e0155390.|[3]Chaturvedi S, et al. Mechanistic exploration of quercetin against metronidazole induced neurotoxicity in rats: Possible role of nitric oxide isoforms and inflammatory cytokines. Neurotoxicology. 2020 Jul;79:1-10.|[4]Manickam R, et al. Metronidazole Causes Skeletal Muscle Atrophy and Modulates Muscle Chronometabolism. Int J Mol Sci. 2018 Aug 16;19 (8) :2418.