GAPDH-IN-1
GAPDH-IN-1 (Compound F8) is a GAPDH inhibitor (IC50 of 39.31 μM for GAPDH enzymatic activity) . GAPDH-IN-1 forms a covalent adduct with an aspartic acid in the active site to displace NAD+, a cofactor of the enzyme, with concomitant enhancement of the cysteine-reactive probe reaction with the catalytic cysteine[1].
Product Specifications
CAS Number
252212-58-1
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/gapdh-in-1.html
Purity
98.1
Smiles
C1(C2=CC(OCC3OC3)=CC=C2)=NN=C(C4=CC(OCC5OC5)=CC=C4)O1
Molecular Formula
C20H18N2O5
Molecular Weight
366.37
References & Citations
[1]Jung Y, et al. Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe. ACS Chem Biol. 2022 Feb 18;17 (2) :340-347.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
TA366481 100 µL
Iduronate 2 sulfatase (IDS) Rabbit Polyclonal Antibody
Sign In for Pricing
View Details 
BNCB1058-100 1x 100 µL
Human Papillomavirus 16 (HPV-16) (HPV16/1058), Biotin conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
GP-8001-10 1 mL
Colloidal Gold Conjugated Tulipa sp. Lectin (Tulip) -TL-, 1mL 10nm
Sign In for Pricing
View Details 
#22032 50x 1 Each
1X TBE (1L) Buffer Powder Packets (box of 50 packets)
Sign In for Pricing
View Details 