CP-601927

CP-601927 is a selective α4β2 nicotinic acetylcholine receptor (nAChR) partial agonist (Ki=1.2 nM; EC50=2.6 μM) . CP-601927 shows good brain penetration and antidepressant-like properties[1][2].

Product Specifications

CAS Number

[357425-02-6]

UNSPSC

12352005

Target

NAChR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cp-601927.html

Purity

98.24

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

FC(C1=CC=C2[C@@H](C3)CNC[C@@H]3C2=C1)(F)F

Molecular Formula

C12H12F3N

Molecular Weight

227.23

References & Citations

[1]Campion SN, et al. Toxicity study in juvenile rats with the α4β2 nicotinic acetylcholine receptor partial agonist CP-601,927. Birth Defects Res B Dev Reprod Toxicol. 2011;92 (4) :323-332.|[2]Mineur YS, et al. α4β2 nicotinic acetylcholine receptor partial agonists with low intrinsic efficacy have antidepressant-like properties. Behav Pharmacol. 2011;22 (4) :291-299.