Tricyclazole

Tricyclazole is a pentaketone melanin biosynthesis inhibitor and a unique fungicide for controlling rice blast. Tricyclazole alters the structure and function of fungal cell walls, reduces fungal pathogenicity and penetration, and causes dose-dependent liver damage in animals[1][2][3][4][5].

Product Specifications

CAS Number

[41814-78-2]

UNSPSC

12352005

Hazard Statement

H302

Target

Fungal

Type

Reference compound

Related Pathways

Anti-infection

Applications

Neuroscience-Neuromodulation

Field of Research

Infection; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/tricyclazole.html

Purity

98.81

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=C2N3C(SC2=CC=C1)=NN=C3

Molecular Formula

C9H7N3S

Molecular Weight

189.24

Precautions

H302

References & Citations

[1]Peterson L.G. Tricyclazole for Control of Pyricularia Oryzae on Rice: the Relationship of the Mode of Action and Disease Occurrence and Development. Pest Management in Rice. Springer, Dordrecht.|[2]G.Lazarovits, et al. Tricyclazole induces melanin shunt products and inhibits altersolanol a accumulation by Alternaria solani. Pesticide Biochemistry and Physiology|[3]Franzen AJ, et al. Effects of tricyclazole (5-methyl-1,2,4-triazol[3,4] benzothiazole), a specific DHN-melanin inhibitor, on the morphology of Fonsecaea pedrosoi conidia and sclerotic cells. Microsc Res Tech. 2006 Sep;69 (9) :729-37. |[4]Woloshuk C P, et al. Action of the antipenetrant, tricyclazole, on appressoria of Pyricularia oryzae[J]. Physiological Plant Pathology, 1983, 22 (2) : 245-IN21.|[5]Fattahi E. Histopathological and Enzymatic Changes in Liver of Mice Treated with Tricyclazole[J]. Medical Laboratory Journal, 2017, 11 (6) : 18-22.