PLX-4545

PLX-4545 is an orally active and selective cereblon-based molecular glue degrader of IKZF2 (zinc finger transcription factor Helios) . PLX-4545 can reprogram immunosuppressive regulatory T cells into pro-inflammatory effector T cells, thereby enhancing anti-tumor immune responses[1].

Product Specifications

CAS Number

[2892065-45-9]

UNSPSC

12352005

Target

IKZF Family; Molecular Glues

Type

Reference compound

Related Pathways

Immunology/Inflammation; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/plx-4545.html

Purity

96.76

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1CC[C@@H](C(N1)=O)N2CC3=C(C2=O)C=CC(O[C@H]4CCCC[C@@H]4N5CC(C5)C6=CC=CC=C6)=C3

Molecular Formula

C28H31N3O4

Molecular Weight

473.56

References & Citations

[1]Huang Y, et al. PLX-4545, a selective IKZF2 degrader, reprograms suppressive Tregs leading to tumor growth inhibition and combination benefit with immune checkpoint therapy[J]. Cancer Research, 2025, 85 (8_Supplement_1) : 6380-6380.