Luteolinidin (chloride)

Luteolinidin chloride is a deoxyanthocyanidin isolated from the plant Sorghum bicolor with antioxidant activity. Luteolinidin chloride is a potent CD38 inhibitor (Ki=11.4 μM) and protects the heart from ischemia/reperfusion injury by preserving endothelial nitric oxide synthase (eNOS) function and preventing endothelial dysfunction. Luteolinidin chloride is also a competitive inhibitor of tyrosinase (IC50=3.7 μM) and blocks the production of melanin[1][2][3][4][5].

Product Specifications

CAS Number

[1154-78-5]

UNSPSC

12352005

Target

CD38; NADPH Oxidase; Tyrosinase

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/luteolinidin-chloride.html

Purity

99.73

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC1=CC2=[O+]C(C3=CC=C(O)C(O)=C3)=CC=C2C(O)=C1.[Cl-]

Molecular Formula

C15H11ClO5

Molecular Weight

306.70

References & Citations

[1]Maria JoãoMelo, et al. Photochemistry of luteolinidin: “Write-lock-read-unlock-erase” with a natural compound. Journal of Photochemistry and Photobiology A: Chemistry|[2]Boslett J, et al. Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD (P) (H) . J Pharmacol Exp Ther. 2017 Apr;361 (1) :99-108.|[3]Bianco-Gomes AC, et al. Dry heat and pressure favor bioactive compounds preservation and peptides formation in sorghum [Sorghum bicolor (L.) Moench][J]. Curr Res Food Sci. 2022 Jan 4;5:117-124.|[4]Boslett J J. CD38 in the Heart: Effects of CD38 Activation on Post-Ischemic Injury[D]. The Ohio State University, 2017.|[5]Yang S Y, et al. The Luteolinidin and Petunidin 3-O-Glucoside: A Competitive Inhibitor of Tyrosinase[J]. Molecules, 2022, 27 (17) : 5703.