Elafin(human)

Elafin,also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus[1][2][3].

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[1]A J Simpson, et al. Elafin (elastase-specific inhibitor) has anti-microbial activity against Gram-positive and Gram-negative respiratory pathogens. FEBS Lett. 1999 Jun 11;452(3):309-13.|[2]Sophie Paczesny, et al. Elafin Is a Biomarker of Graft-Versus-Host Disease of the Skin. Sci Transl Med. 2010 Jan 6;2(13):13ra2.|[3]Lee Shaw, et al. Therapeutic potential of human elafin. Biochem Soc Trans. 2011 Oct;39(5):1450-4.