Elafin (human)

Elafin, also known as elafin-specific inhibitor (ESI) or skin anti-leucoprotease (SKALP), is a low molecular weight inhibitor of human neutrophil elastase (HNE) and proteinase 3 in lung. Elafin is antibiotic against Pseudomonas aeruginosa and Staphylococcus aureus[1][2][3].

Product Specifications

UNSPSC

12352209

Target

Bacterial; Elastase

Type

Peptides

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/elafin-human.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(NCC(N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@H](C(NCC(N[C@H](C(N[C@H](C(N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N5[C@H](C(N6[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N7[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H]8CCCCN)=O)CCCCN)=O)[C@H](CC)C)=O)=O)CCC7)=O)CSSC[C@H](NC9=O)C(N[C@H](C(N[C@H](C(N%10[C@H](C(N[C@H](C(O)=O)CCC(N)=O)=O)CCC%10)=O)C(C)C)=O)CC%11=CC=CC=C%11)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)CC(O)=O)=O)CCCCN)=O)CC(C)C)=O)CSSC[C@@H]%12NC8=O)=O)CCCNC(N)=N)=O)CC(N)=O)=O)CCC6)=O)CCC5)=O)CC(N)=O)=O)CC(C)C)=O)CCSC)=O)C)=O)CSSC[C@H](NC%13=O)C(NCC(N[C@H](C(N[C@H]9C)=O)CCSC)=O)=O)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)CC(C)C)=O)[C@H](CC)C)=O)[C@H](CC)C)=O)CCC4)=O)CSSC[C@H](NC%12=O)C(N[C@H](C(NCC(N[C@H]%13CO)=O)=O)CCC(O)=O)=O)=O)CO)=O)=O)CCC3)=O)CCCCN)=O)[C@@H](C)O)=O)CO)=O)C(C)C)=O)CCC2)=O)=O)CCCCN)=O)C(C)C)=O)CCC1)=O)CCC(O)=O)=O)CCC(N)=O

Molecular Formula

C254H416N72O75S10

Molecular Weight

5999.11

References & Citations

[1]A J Simpson, et al. Elafin (elastase-specific inhibitor) has anti-microbial activity against Gram-positive and Gram-negative respiratory pathogens. FEBS Lett. 1999 Jun 11;452 (3) :309-13.|[2]Sophie Paczesny, et al. Elafin Is a Biomarker of Graft-Versus-Host Disease of the Skin. Sci Transl Med. 2010 Jan 6;2 (13) :13ra2.|[3]Lee Shaw, et al. Therapeutic potential of human elafin. Biochem Soc Trans. 2011 Oct;39 (5) :1450-4.