Sepantronium (bromide)

Sepantronium bromide (YM-155) is a survivin inhibitor with an IC50 of 0.54 nM[1].

Product Specifications

CAS Number

[781661-94-7]

Product Name Alternative

YM-155

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; Survivin

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/YM-155.html

Purity

99.36

Solubility

DMSO : 11.67 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C(C3=CC=CC=C31)=O)[N+](CC4=NC=CN=C4)=C(C)N2CCOC.[Br-]

Molecular Formula

C20H19BrN4O3

Molecular Weight

443.29

Precautions

H302, H315, H319, H335

References & Citations

[1]Nakahara T, et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67 (17) :8014-21.|[2]Iisa T, et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res. 2008 Oct 15;14 (20) :6496-504.|[3]Guo K, et al. A combination of YM-155, a small molecule survivin inhibitor, and IL-2 potently suppresses renal cell carcinoma in murine model. Oncotarget. 2015 Aug 28;6 (25) :21137-47.