(S) -NIK SMI1

(S) -NIK SMI1 is the isomer of NIK SMI1 (HY-112433), and can be used as an experimental control. NIK SMI1 is a potent, selective NF-κB inducing kinase (NIK) inhibitor, which inhibits NIK-catalyzed hydrolysis of ATP to ADP with IC50 of 0.23±0.17 nM.

Product Specifications

CAS Number

[2984765-48-0]

UNSPSC

12352005

Target

NF-κB

Type

Reference compound

Related Pathways

NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/s-nik-smi1.html

Concentration

10mM

Purity

99.28

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N)C1=NC(C2=CC=CC(C#C[C@@]3(O)CCN(C)C3=O)=C2)=CC(OC)=C1

Molecular Formula

C20H19N3O4

Molecular Weight

365.38

References & Citations

[1]Blaquiere N, et al. Scaffold-Hopping Approach To Discover Potent, Selective, and Efficacious Inhibitors of NF-κB Inducing Kinase. J Med Chem. 2018 Aug 9;61 (15) :6801-6813.