Sotalol-d6 (hydrochloride)

Sotalol-d6 (hydrochloride) is a deuterium labeled Sotalol hydrochloride. Sotalol hydrochloride is an orally active, non-selective competitive β-adrenergic receptor blocker. Sotalol hydrochloride is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol hydrochloride blocks β-receptors, and potassium KCNH2 channels[1][2].

Product Specifications

CAS Number

[1246820-85-8]

Product Name Alternative

MJ 1999-d6 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Adrenergic Receptor; Potassium Channel

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Cardiovascular Disease

Purity

98.01

Solubility

10 mM in DMSO

Smiles

OC(C1=CC=C(NS(C)(=O)=O)C=C1)CNC(C([2H])([2H])[2H])C([2H])([2H])[2H].[H]Cl

Molecular Formula

C12H15D6ClN2O3S

Molecular Weight

314.86

Precautions

H315, H319, H335

References & Citations

[1]Marta Reyes-Corral, et al. Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. J Pharmacol Exp Ther. 2019 Apr;369 (1) :152-162.|[2]Xiaomei Li, et al. Pediatric Dosing of Intravenous Sotalol Based on Body Surface Area in Patients with Arrhythmia. Pediatr Cardiol. 2017 Oct;38 (7) :1450-1455.