ISX9
Induces neuronal differentiation
Product Specifications
Background
Promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory (1). Induces robust neuronal differentiation in adult neural stem cells (2). Increases insulin production by pancreatic βcells (3). Blocks malignant astrocyte proliferation, downregulates their astrocyte character, induces reentry into the cell cycle and upregulates neuronal gene expression (4). Induces sensory neurons from neuroepithelial stem cells (5). Potentiates cell proliferation and neuronal commitment in the rat dentate gyrus (6).
CAS Number
832115-62-5
Product Name Alternative
N-Cyclopropyl-5- (2-thienyl) -3-isoxazolecarboxamide; ISX; Isoxazole-9
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Neuroscience | Neurotransmission | Calcium Signaling | Calmodulin | CamK | Stem Cells
Purity
>99% (TLC) ; NMR (Conforms)
Weight
0.005
Format
Tan powder
Solubility
May be dissolved in DMSO (60 mg/ml): or ethanol (16 mg/ml, warm)
Molecular Formula
C11H10N2O2S
Molecular Weight
234.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. D Petrick et al. FASEB J. 2012 26:3148
2. JW Schneider et al. Nat. Chem. Biol. 2008 4:408
3. EM Dioum et al. Proc. Natl. Acad. Sci. U.S.A. 2011 108:20713
4. L Zhang et al. Differentiation 2011 81:233
5. RQ Ali et al. Am. J. Stem Cells 2016 5:19
6. LE Bettio et al. Neuroscience 2016 332:212
Curated Selection
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