ISX9

Promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory (1). Induces robust neuronal differentiation in adult neural stem cells (2). Increases insulin production by pancreatic βcells (3). Blocks malignant astrocyte proliferation, downregulates their astrocyte character, induces reentry into the cell cycle and upregulates neuronal gene expression (4). Induces sensory neurons from neuroepithelial stem cells (5). Potentiates cell proliferation and neuronal commitment in the rat dentate gyrus (6).

1. D Petrick et al. FASEB J. 2012 26:3148 2. JW Schneider et al. Nat. Chem. Biol. 2008 4:408 3. EM Dioum et al. Proc. Natl. Acad. Sci. U.S.A. 2011 108:20713 4. L Zhang et al. Differentiation 2011 81:233 5. RQ Ali et al. Am. J. Stem Cells 2016 5:19 6. LE Bettio et al. Neuroscience 2016 332:212