ISX9

Induces neuronal differentiation

Product Specifications

Background

Promotes neurogenesis in vivo enhancing the proliferation and differentiation of hippocampal subgranular zone neuroblasts and enhances memory (1). Induces robust neuronal differentiation in adult neural stem cells (2). Increases insulin production by pancreatic βcells (3). Blocks malignant astrocyte proliferation, downregulates their astrocyte character, induces reentry into the cell cycle and upregulates neuronal gene expression (4). Induces sensory neurons from neuroepithelial stem cells (5). Potentiates cell proliferation and neuronal commitment in the rat dentate gyrus (6).

Product Name Alternative

N-Cyclopropyl-5-(2-thienyl)-3-isoxazolecarboxamide; ISX; Isoxazole-9

UNSPSC

41116105

Source

Synthetic

Purity

>99% (TLC); NMR (Conforms)

Weight

0.005

Format

Tan powder

Solubility

May be dissolved in DMSO (60 mg/ml): or ethanol (16 mg/ml, warm)

Molecular Formula

C11H10N2O2S

Molecular Weight

234.3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. D Petrick et al. FASEB J. 2012 26:3148 2. JW Schneider et al. Nat. Chem. Biol. 2008 4:408 3. EM Dioum et al. Proc. Natl. Acad. Sci. U.S.A. 2011 108:20713 4. L Zhang et al. Differentiation 2011 81:233 5. RQ Ali et al. Am. J. Stem Cells 2016 5:19 6. LE Bettio et al. Neuroscience 2016 332:212