(2R,5S) -Ritlecitinib
(2R,5S) -Ritlecitinib (2R,5S) -PF-06651600) is a JAK3 inhibitor (IC50=144.8 nM) [1][2].
Product Specifications
CAS Number
1792180-79-0
Product Name Alternative
(2R,5S) -PF-06651600
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/2r-5s-ritlecitinib.html
Concentration
10mM
Purity
99.77
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[C@@H]1CC[C@@H](CN1C(C=C)=O)NC2=C3C=CNC3=NC=N2
Molecular Formula
C15H19N5O
Molecular Weight
285.35
References & Citations
[1]Matthew Frank, et al. Pyrrolo[2,3-d]pyrimidinyl-, pyrrolo[2,3-b]pyrazinyl-and pyrrolo[2,3-d]pyridinylacrylamides as JAK inhibitor and their preparation. World Intellectual Property Organization, WO2015083028 A1 2015-06-11.|[2]Thorarensen A, et al. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1- ((2 S, 5 R) -5- ((7 H-Pyrrolo [2, 3-d] pyrimidin-4-yl) amino) -2-methylpiperidin-1-yl) prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans. Journal of medicinal chemistry, 2017, 60 (5) : 1971-1993.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK3
Available Sizes
Frequently Asked Questions
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