Z-Phe-Leu-Glu-pNA

Z-Phe-Leu-Glu-pNA is a chromogenic substrate for glutamyl endopeptidases. Z-Phe-Leu-Glu-pNA has been used as a synthetic substrate in the study of proteolytic enzymes, including trypsin treatment, subtilisin and chymotrypsin. Z-Phe-Leu-Glu-pNA plays an important role in hormone disorders such as prostate cancer and breast cancer[1][2].

Product Specifications

CAS Number

[104634-10-8]

UNSPSC

12352209

Target

Bacterial

Type

Peptides

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/z-phe-leu-glu-pna.html

Purity

98.05

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=[N+]([O-])C(C=C1)=CC=C1NC([C@H](CCC(O)=O)NC([C@H](CC(C)C)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O)=O

Molecular Formula

C34H39N5O9

Molecular Weight

661.70

References & Citations

[1]Wei Ye, et al. Characterization of the glutamate-specific endopeptidase from Bacillus licheniformis expressed in Escherichia coli. J Biotechnol. 2013 Oct 10;168 (1) :40-5.|[2]Wei Ye, et al. A new strategy for recovery of two peptides without Glu employing glutamate-specific endopeptidase from Bacillus licheniformis. Enzyme Microb Technol. 2014 Jan 10:54:25-31.