Indophagolin

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM) . Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM) . Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].

Product Specifications

CAS Number

[1207660-00-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

5-HT Receptor; Autophagy; P2X Receptor

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/indophagolin.html

Purity

98.05

Solubility

DMSO : 250 mg/mL (ultrasonic; warming)

Smiles

O=S(C1=CC2=C(C=C1Br)CCN2C(C3CC3)=O)(NC4=CC=C(Cl)C(C(F)(F)F)=C4)=O

Molecular Formula

C19H15BrClF3N2O3S

Molecular Weight

523.75

Precautions

H302, H315, H319, H335

References & Citations

[1]Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021; S2451-9456 (21) 00102-1.