Diprotin B

Diprotin B is a dipeptidyl aminopeptidase IV (DPP IV) inhibitor. The apparent competitive inhibition of DPP-IV by the diprotins is a kinetic artifact, derived from the substrate-like nature of tripeptides containing a penultimate proline residue[1][2].

Product Specifications

CAS Number

[90614-49-6]

UNSPSC

12352209

Hazard Statement

H302

Target

Dipeptidyl Peptidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/diprotin-b.html

Purity

99.60

Solubility

H2O : ≥ 100 mg/mL

Smiles

CC(C)C[C@@H](C(O)=O)NC([C@H]1N(C([C@H](C(C)C)N)=O)CCC1)=O

Molecular Formula

C16H29N3O4

Molecular Weight

327.42

Precautions

H302

References & Citations

[1]Rahfeld J, et al. Are diprotin A (Ile-Pro-Ile) and diprotin B (Val-Pro-Leu) inhibitors or substrates of dipeptidyl peptidase IV? Biochim Biophys Acta. 1991 Jan 29;1076 (2) :314-6.|[2]Hatanaka T, et al. Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity. J Enzyme Inhib Med Chem. 2014 Dec;29 (6) :823-8.