AV-412

AV-412 (MP412) is an EGFR inhibitor with IC50s of 0.75, 0.5, 0.79, 2.3, 19 nM for EGFR, EGFRL858R, EGFRT790M, EGFRL858R/T790M and ErbB2, respectively.

Product Specifications

CAS Number

[451493-31-5]

Product Name Alternative

MP412

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AV-412.html

Concentration

10mM

Purity

99.17

Solubility

DMSO : ≥ 28 mg/mL

Smiles

O=S(C1=CC=C(C)C=C1)(O)=O.C=CC(NC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2C#CC(N5CCN(C)CC5)(C)C)=O.O=S(C6=CC=C(C)C=C6)(O)=O

Molecular Formula

C41H44ClFN6O7S2

Molecular Weight

851.41

Precautions

H302, H315, H319, H335

References & Citations

[1]Suzuki T, et al. Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptorand ErbB2 tyrosine kinase inhibitor. Cancer Sci. 2007 Dec;98 (12) :1977-84.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Isoform

EGFR/ErbB1/HER1; ErbB2/HER2

Citation 01

Cancer Med. 2024 May;13 (10) :e7083.|Nature. 2025 Nov 26.|Proc Natl Acad Sci U S A. 2019 Feb 19;116 (8) :2996-3005. |Sci Data. 2024 Sep 19;11 (1) :1024.|Science. 2017 Dec 1;358 (6367) :eaan4368.