palm-PrRP31

palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC50=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure[1].

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[1]Strnadová V, et al. Search for lipidized PrRP analogs with strong anorexigenic effect: in vitro and in vivo studies[J]. Neuropeptides, 2023, 98: 102319.