N-CBZ-Phe-Arg-AMC

N-CBZ-Phe-Arg-AMC (Z-FR-AMC) is a cathepsin substrate used in assessment activity of lysosomal cathepsin enzymes[1][2].

Product Specifications

CAS Number

[65147-22-0]

Product Name Alternative

Z-FR-AMC

UNSPSC

12352209

Hazard Statement

H302-H315-H319-H335

Target

Cathepsin

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-cbz-phe-arg-amc.html

Purity

99.88

Solubility

10 mM in DMSO

Smiles

CC(C1=CC=C(NC([C@H](CCCNC(N)=N)NC([C@@H](NC(OCC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)=O)C=C1O4)=CC4=O

Molecular Formula

C33H36N6O6

Molecular Weight

612.68

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Xu P, et al. Ascorbic acid modulation of iron homeostasis and lysosomal function in trabecular meshwork cells. J Ocul Pharmacol Ther. 2014 Mar-Apr;30 (2-3) :246-53.|[2]Porter K, et al. Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis. Autophagy. 2013 Apr;9 (4) :581-94.