Leucomethylene blue (mesylate)

Leucomethylene blue (TRx0237) mesylate, an orally active second-generation tau protein aggregation inhibitor (Ki of 0.12 μM), could be used for the study of Alzheimer's Disease. Leucomethylene blue mesylate is a common reduced form of Methylene Blue, Methylene Blue is a member of the thiazine class of dyes[1][2][3].

Product Specifications

CAS Number

[1236208-20-0]

Product Name Alternative

TRx0237 (mesylate) ; Methylene blue leuco base (mesylate)

UNSPSC

12171500

Hazard Statement

H302, H315, H319, H335

Target

Tau Protein

Type

Dye Reagents

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/leucomethylene-blue-mesylate.html

Purity

98.75

Solubility

DMSO : 75 mg/mL (ultrasonic) |H2O : 83.33 mg/mL (ultrasonic)

Smiles

CN(C)C1=CC(SC2=CC(N(C)C)=CC=C2N3)=C3C=C1.CS(=O)(O)=O.CS(=O)(O)=O

Molecular Formula

C18H27N3O6S3

Molecular Weight

477.62

Precautions

H302, H315, H319, H335

References & Citations

[1]Gaudette NF, et al. Determination of methylene blue and leucomethylene blue in male and female Fischer 344 rat urine andB6C3F1 mouse urine. J Anal Toxicol. 2005 Jan-Feb;29 (1) :28-33.|[2]Zhenhua Liu, et al. Amyloid β and tau are involved in sleep disorder in Alzheimer's disease by orexin A and adenosine A (1) receptor. Int J Mol Med. 2019 Jan;43 (1) :435-442.|[3]Francesco Panza, et al. Tau aggregation inhibitors: the future of Alzheimer's pharmacotherapy? Expert Opin Pharmacother. 2016;17 (4) :457-61.