Tos-PEG2-O-Propargyl
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458) [1]. Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[1119249-30-7]
UNSPSC
12352005
Hazard Statement
H301, H311, H331, H341
Target
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tos-peg2-o-propargyl.html
Purity
99.34
Solubility
Ethanol : 50 mg/mL (ultrasonic)
Smiles
C#CCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Molecular Formula
C14H18O5S
Molecular Weight
298.36
Precautions
H301, H311, H331, H341
References & Citations
[1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61 (2) :453-461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PEG Linkers
Available Sizes
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