Tos-PEG2-O-Propargyl

Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458) [1]. Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[1119249-30-7]

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tos-peg2-o-propargyl.html

Purity

99.34

Solubility

Ethanol : 50 mg/mL (ultrasonic)

Smiles

C#CCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O

Molecular Formula

C14H18O5S

Molecular Weight

298.36

Precautions

H301, H311, H331, H341

References & Citations

[1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61 (2) :453-461.