Tos-PEG2-O-Propargyl
Product Specifications
UNSPSC Description
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1]. Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tos-peg2-o-propargyl.html
Purity
98.47
Solubility
Ethanol : 50 mg/mL (ultrasonic)
Smiles
C#CCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O
Molecular Weight
298.36
References & Citations
[1]Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130162/Tos-PEG2-O-Propargyl-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130162/Tos-PEG2-O-Propargyl-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1119249-30-7
Available Sizes
Curated Selection
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