Clomesone

Clomesone (NSC 338947) is a compound with antitumor activity. Clomesone induces the formation of cross-links between DNA strands in cell lines. Clomesone is inactive against most human colorectal cancer solid tumor cell lines in vitro, has no significant activity against mouse tumors in vivo, and is accompanied by bone marrow suppression. Its pharmacokinetic behavior indicates that it cannot reach effective concentrations at the tumor site.

Product Specifications

CAS Number

[88343-72-0]

Product Name Alternative

NSC 338947; CIEtSoSo

UNSPSC

12352100

Hazard Statement

H302-H315-H319-H335

Target

DNA Alkylator/Crosslinker

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/clomesone.html

Smiles

O=S(OCCCl)(CS(=O)(C)=O)=O

Molecular Formula

C4H9ClO5S2

Molecular Weight

236.69

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Pre-clinical evaluation of a novel chloroethylating agent, Clomesone|[2]M E Dolan, et al. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl (methylsulfonyl) methanesulfonate. Cancer Res. 1988 Jul 1;48 (13) :3603-6.