ML 315
Product Specifications
Product Name Alternative
4-Nitrophenylphosphorylcholine; 4-Nitrophenylphosphorylcholine; O-(4-Nitrophenylphosphoryl)choline
UNSPSC Description
ML 315 is a selective dual inhibitor of CDK and DYRK with IC50s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research[1].
Target Antigen
CDK; DYRK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ml-315.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(CNC2=NC=NC=C2C3=CC=C4OCOC4=C3)=CC(Cl)=C1
Molecular Weight
374.22
References & Citations
[1]Coombs TC, et al. Small-molecule pyrimidine inhibitors of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases: development of chemical probe ML315. Bioorg Med Chem Lett. 2013 Jun 15;23(12):3654-61.
Shipping Conditions
Room temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117608/ML-315-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117608/
Clinical Information
No Development Reported
CAS Number
1440251-53-5
Available Sizes
Curated Selection
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