Senaparib (hydrochloride)

Senaparib hydrochloride (IMP4297 hydrochloride) is an oral, selective PARP1/2 inhibitor with potent anti-tumor activity. Senaparib hydrochloride shows antitumor activity against advanced ovarian cancer[1].

Product Specifications

CAS Number

[1401683-39-3]

Product Name Alternative

IMP4297 (hydrochloride) ; JS109 (hydrochloride)

UNSPSC

12352005

Target

PARP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/senaparib-hydrochloride.html

Smiles

O=C1NC(N(CC2=CC=C(C(C(N3CCN(CC3)C4=NC=CC=N4)=O)=C2)F)C5=C1C(F)=CC=C5)=O.Cl

Molecular Formula

C24H21ClF2N6O3

Molecular Weight

514.91

References & Citations

[1]P. de Souza, et al. 574P Updated results of phase I study of senaparib (IMP4297) in Australian patients with advanced solid tumours. ABSTRACT ONLY| VOLUME 31, SUPPLEMENT 4, S490, SEPTEMBER 01, 2020.|[2]Senaparib as first-line maintenance therapy in advanced ovarian cancer: a randomized phase 3 trial