NU 7026
NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM.
Product Specifications
CAS Number
154447-35-5
Product Name Alternative
LY293646
UNSPSC
12352005
Hazard Statement
H302
Target
Apoptosis; DNA-PK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NU-7026.html
Purity
99.97
Solubility
DMSO : 2.5 mg/mL (ultrasonic)
Smiles
O=C1C2=CC=C3C=CC=CC3=C2OC(N4CCOCC4)=C1
Molecular Formula
C17H15NO3
Molecular Weight
281.31
Precautions
H302
References & Citations
[1]Veuger SJ, et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly (ADP-ribose) polymerase-1. Cancer Res. 2003 Sep 15;63 (18) :6008-15.|[2]Amrein L, et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2- (morpholin-4-yl) -benzo[h]chomen-4-one (NU7026) -mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J|[3]Nutley BP, et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer. 2005 Oct 31;93 (9) :1011-8.|[4]Ciszewski WM, et al. Interleukin-4 enhances PARP-dependent DNA repair activity in vitro. J Interferon Cytokine Res. 2014 Sep;34 (9) :734-40.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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