NU 7026

NU 7026 (LY293646) is a novel specific DNA-PK inhibitor with IC50 of 0.23 μM, also inhibits PI3K with IC50 of 13 μM.

Product Specifications

CAS Number

[154447-35-5]

Product Name Alternative

LY293646

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; DNA-PK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NU-7026.html

Purity

99.97

Solubility

DMSO : 2.5 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=C3C=CC=CC3=C2OC(N4CCOCC4)=C1

Molecular Formula

C17H15NO3

Molecular Weight

281.31

Precautions

H302

References & Citations

[1]Veuger SJ, et al. Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly (ADP-ribose) polymerase-1. Cancer Res. 2003 Sep 15;63 (18) :6008-15.|[2]Amrein L, et al. Chlorambucil cytotoxicity in malignant B lymphocytes is synergistically increased by 2- (morpholin-4-yl) -benzo[h]chomen-4-one (NU7026) -mediated inhibition of DNA double-strand break repair via inhibition of DNA-dependent protein kinase. J|[3]Nutley BP, et al. Preclinical pharmacokinetics and metabolism of a novel prototype DNA-PK inhibitor NU7026. Br J Cancer. 2005 Oct 31;93 (9) :1011-8.|[4]Ciszewski WM, et al. Interleukin-4 enhances PARP-dependent DNA repair activity in vitro. J Interferon Cytokine Res. 2014 Sep;34 (9) :734-40.