Milbemycin A4 oxime
Milbemycin A4 oxime (5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime) is a derivative of Milbemycin A4 (HY-126906) and a component of Milbemycin oxime (HY-B0778), both of which have insecticidal and nematicidal activities. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae in naturally infected dogs with D. immitis and inhibits the growth of clinical isolates of Candida glabrata (MIC80=16-32 μg/mL) . Milbemycin A4 oxime (2.5 μg/mL) blocks the efflux of Fluconazole (HY-B0101) from clinical isolates of Candida glabrata. Milbemycin A4 oxime enhances doxorubicin-induced cell growth inhibition and increases the intracellular accumulation of doxorubicin and P-glycoprotein substrate Rhodamine 123 (HY-D0816) in doxorubicin-resistant but not sensitive MCF-7 breast cancer cells in a concentration-dependent manner.
Product Specifications
CAS Number
[93074-04-5]
Product Name Alternative
5-Ketomilbemycin A4 oxime; 5-Oxomilbemycin A4 5-oxime
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/milbemycin-a4-oxime.html
Smiles
O[C@@]([C@@](C(O[C@]1([H])C[C@](O[C@@H]2CC)(CC[C@@H]2C)O[C@@]3([H])C1)=O)([H])C=C/4C)(/C5=C/C=C/[C@@H](C/C(C)=C/C3)C)[C@@](OC5)([H])C4=N\O
Molecular Formula
C32H45NO7
Molecular Weight
555.70
References & Citations
[1]Walker, et al. Milbemycin A4 oxime as a probe of azole transport in Candida glabrata. FEMS Yeast Res. 14 (5), 755-761 (2014) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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