HA-100
HA-100 is a potent protein kinase inhibitor, with IC50s of 4 μM, 8 μM, 12 μM and 240 μM for cGMP-dependent protein kinase (PKG), cAMP-dependent protein kinase (PKA), protein kinase C (PKC) and MLC-kinase, respectively. HA-100 also used as a ROCK inhibitor[1][2].
Product Specifications
CAS Number
84468-24-6
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Myosin; PKA; PKC; ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/HA-100.html
Purity
99.87
Solubility
DMSO : 150 mg/mL (ultrasonic; warming)
Smiles
O=S(C1=CC=CC2=C1C=CN=C2)(N3CCNCC3)=O
Molecular Formula
C13H15N3O2S
Molecular Weight
277.34
Precautions
H315, H319
References & Citations
[1]Hagiwara M, et al. Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives. Mol Pharmacol. 1987 Jul;32 (1) :7-12.|[2]Yu J, et, al. Efficient feeder-free episomal reprogramming with small molecules. PLoS One. 2011 Mar 1;6 (3) :e17557.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKC
Available Sizes
Frequently Asked Questions
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