ADX-10061
ADX-10061 (compound NNC 687) is a dopamine D1 receptor antagonist with the Ki values of 9.1 nM, 5.8 nM, > 10 000 nM and 355 nM for adenylyl cyclase, D1, D2 and 5-HT2 receptor, respectively. ADX-10061 can be used for study of schizophrenia[1].
Product Specifications
CAS Number
128022-68-4
Product Name Alternative
CEE 03-310; NNC 687
UNSPSC
12352005
Target
Adenylate Cyclase; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/adx-10061.html
Smiles
OC1=C([N+]([O-])=O)C=C2CCN(C)C[C@H](C3=C(OCC4)C4=CC=C3)C2=C1
Molecular Formula
C19H20N2O4
Molecular Weight
340.37
References & Citations
[1]Andersen PH, et al. NNC-112, NNC-687 and NNC-756, new selective and highly potent dopamine D1 receptor antagonists. Eur J Pharmacol. 1992;219 (1) :45-52.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
D1 Receptor; D2 Receptor
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