HC-Toxin
Product Specifications
UNSPSC Description
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2].
Target Antigen
Apoptosis; HDAC
Type
Natural Products
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hc-toxin.html
Purity
99.26
Solubility
10 mM in DMSO
Smiles
O=C([C@@H](NC([C@H]1C)=O)CCCCCC([C@@H]2CO2)=O)N3[C@](C(N[C@H](C(N1)=O)C)=O)([H])CCC3
Molecular Weight
436.50
References & Citations
[1]S J Darkin-Rattray, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.|[2]Ki Eun Joung, et al. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Arch Pharm Res. 2004 Jun;27(6):640-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126856/HC-Toxin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126856/HC-Toxin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
83209-65-8
Available Sizes
Curated Selection
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