HC-Toxin

HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2].

Product Specifications

CAS Number

[83209-65-8]

UNSPSC

12352005

Hazard Statement

H300

Target

Apoptosis; HDAC

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hc-toxin.html

Purity

99.26

Solubility

10 mM in DMSO|DMSO : ≥ 10mg/mL

Smiles

O=C([C@@H](NC([C@H]1C)=O)CCCCCC([C@@H]2CO2)=O)N3[C@](C(N[C@H](C(N1)=O)C)=O)([H])CCC3

Molecular Formula

C21H32N4O6

Molecular Weight

436.50

Precautions

P264-P270-P330-P405-P501

References & Citations

[1]S J Darkin-Rattray, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996 Nov 12;93 (23) :13143-7.|[2]Ki Eun Joung, et al. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Arch Pharm Res. 2004 Jun;27 (6) :640-5.