HC-Toxin
HC-Toxin, a cyclic tetrapeptide, is a potent HDAC inhibitor with an IC50 of 30 nM[1]. HC-Toxin induces tumor cell apoptosis and has anticancer effects[2].
Product Specifications
CAS Number
83209-65-8
UNSPSC
12352005
Hazard Statement
H300
Target
Apoptosis; HDAC
Type
Natural Products
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hc-toxin.html
Purity
99.26
Solubility
10 mM in DMSO|DMSO : ≥ 10mg/mL
Smiles
O=C([C@@H](NC([C@H]1C)=O)CCCCCC([C@@H]2CO2)=O)N3[C@](C(N[C@H](C(N1)=O)C)=O)([H])CCC3
Molecular Formula
C21H32N4O6
Molecular Weight
436.50
Precautions
P264-P270-P330-P405-P501
References & Citations
[1]S J Darkin-Rattray, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996 Nov 12;93 (23) :13143-7.|[2]Ki Eun Joung, et al. Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells. Arch Pharm Res. 2004 Jun;27 (6) :640-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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