Ethonafide
Product Specifications
UNSPSC Description
Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β[1].
Target Antigen
Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ethonafide.html
Smiles
O=C1N(CCN(C)C)C(C2=CC=C(OCC)C3=CC4=CC=CC=C4C1=C23)=O
Molecular Weight
362.42
References & Citations
[1]Alan Pourpak, et al. Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells. J Pharmacol Exp Ther. 2007 Jun;321(3):1109-17.|[2]S M Sami, et al. 6- and 7-substituted 2-[2'-(dimethylamino)ethyl]-1,2-dihydro-3H-dibenz[de,h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships. J Med Chem. 1996 Apr 12;39(8):1609-18.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117543/Ethonafide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117543/
Clinical Information
No Development Reported
CAS Number
160554-87-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
