Ethonafide

Ethonafide (AMP-53) is an anthracene-containing derivative of Amonafide that belongs to the Azonafide series of anticancer agents. Ethonafide (AMP-53) inhibits topoisomerase II activity by stabilizing the enzyme-DNA complex, involving both topoisomerase IIα and β[1].

Product Specifications

CAS Number

[160554-87-0]

Product Name Alternative

AMP-53; 6-Ethoxyazonafide

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ethonafide.html

Smiles

O=C1N(CCN(C)C)C(C2=CC=C(OCC)C3=CC4=CC=CC=C4C1=C23)=O

Molecular Formula

C22H22N2O3

Molecular Weight

362.42

References & Citations

[1]Alan Pourpak, et al. Ethonafide-induced cytotoxicity is mediated by topoisomerase II inhibition in prostate cancer cells. J Pharmacol Exp Ther. 2007 Jun;321 (3) :1109-17.|[2]S M Sami, et al. 6- and 7-substituted 2-[2'- (dimethylamino) ethyl]-1,2-dihydro-3H-dibenz[de, h] isoquinoline-1,3-diones: synthesis, nucleophilic displacements, antitumor activity, and quantitative structure-activity relationships. J Med Chem. 1996 Apr 12;39 (8) :1609-18.