Nrf2 degrader 1
Nrf2 degrader 1 (compound 1) is a PROTAC Nrf2 degrader with anticancer effects. Nrf2 degrader 1 inhibits cancer cells growth for A549 and LK-2 cells with IC50 values of 100 nM and 40 nM, respectively[1].
Product Specifications
CAS Number
[3025286-00-1]
UNSPSC
12352005
Target
Keap1-Nrf2; PROTACs
Type
Reference compound
Related Pathways
NF-κB; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nrf2-degrader-1.html
Purity
99.12
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC(C(N2C(C(C(NCCOCCOC3=CC(CC(NC4=NC(C5=CC=C(N(C(C6=C(C)C=CC=C6)=O)CC7)C7=C5)=C(C)S4)=O)=CC=C3)=CC=C8)=C8C2=O)=O)CC1)=O
Molecular Formula
C45H42N6O8S
Molecular Weight
826.92
References & Citations
[1]John Edwin Munroe, et al. Nrf2 protein degraders. WO2024006742A2.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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