BAY-549
BAY-549 (Azaindole 1), a chemical probe, is an orally active and ATP-competitive ROCK inhibitor with IC50s of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2, respectively[1].
Product Specifications
CAS Number
867017-68-3
Product Name Alternative
ROCK-IN-2; Azaindole 1; TC-S 7001
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
COVID-19-anti-virus
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/bay-549.html
Purity
99.46
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
NC1=NC(Cl)=CC(NC2=CC(F)=C(OC3=C4C(NC=C4C)=NC=C3)C(F)=C2)=N1
Molecular Formula
C18H13ClF2N6O
Molecular Weight
402.79
Precautions
H302, H315, H319, H335
References & Citations
[1]Kast R, et al. Cardiovascular effects of a novel potent and highly selective azaindole-based inhibitor of Rho-kinase. Br J Pharmacol. 2007 Dec;152 (7) :1070-80. Epub 2007 Oct 15.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK1; ROCK2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC681236-100 1x 100 µL
PTH (Parathyroid Hormone) (N & C Terminal) (3H9 + PTH/1175), CF568 conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC472123-500 1x 500 µL
Mammaglobin (SCGB2A2) (Breast Cancer Marker) (MGB1/2123R), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![Myeloid leukemia factor 1 (MLF1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3A3]](https://cdn.genprice.uk/products/937/6868c367994c49e6dc3f5c7d/imageurl/ta504764am.webp)
TA504764AM 100 µL
Myeloid leukemia factor 1 (MLF1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3A3]
Sign In for Pricing
View Details