Bz 423

Bz 423 is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes, and activates Bax and Bak.

Product Specifications

CAS Number

[216691-95-1]

Product Name Alternative

BZ48

UNSPSC

12352005

Target

Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/Bz_423.html

Purity

99.72

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C1N(C)C2=CC=C(Cl)C=C2C(C3=CC=C(O)C=C3)=NC1CC4=CC=C5C=CC=CC5=C4

Molecular Formula

C27H21ClN2O2

Molecular Weight

440.92

References & Citations

[1]Blatt NB, et al. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem Pharmacol. 2009 Oct 15;78 (8) :966-73.|[2]Blatt NB, et al. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free Radic Biol Med. 2008 Nov 1;45 (9) :1232-42.