Bz 423
Bz 423 is a pro-apoptotic 1,4-benzodiazepine with therapeutic properties in murine models of lupus demonstrating selectivity for autoreactive lymphocytes, and activates Bax and Bak.
Product Specifications
CAS Number
[216691-95-1]
Product Name Alternative
BZ48
UNSPSC
12352005
Target
Bcl-2 Family
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Bz_423.html
Purity
99.72
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C1N(C)C2=CC=C(Cl)C=C2C(C3=CC=C(O)C=C3)=NC1CC4=CC=C5C=CC=CC5=C4
Molecular Formula
C27H21ClN2O2
Molecular Weight
440.92
References & Citations
[1]Blatt NB, et al. Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax. Biochem Pharmacol. 2009 Oct 15;78 (8) :966-73.|[2]Blatt NB, et al. Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax. Free Radic Biol Med. 2008 Nov 1;45 (9) :1232-42.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bak; Bax
Available Sizes
Curated Selection
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