(E/Z) -Mirin
(E/Z) -Mirin is a mixture of (E) -Mirin and Mirin ((Z) -Mirin) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity[1][2].
Product Specifications
CAS Number
299953-00-7
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mirin-1.html
Concentration
10mM
Purity
99.22
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C1N=C(N)S/C1=C/C2=CC=C(O)C=C2
Molecular Formula
C10H8N2O2S
Molecular Weight
220.25
Precautions
H315, H319, H335
References & Citations
[1]Dupré A, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008;4 (2) :119-125.|[2]Ying S, et al. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72 (11) :2814-2821.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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