(E/Z) -Mirin

(E/Z) -Mirin is a mixture of (E) -Mirin and Mirin ((Z) -Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1) . Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity[1][2].

Product Specifications

CAS Number

[299953-00-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mirin-1.html

Concentration

10mM

Purity

99.22

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

O=C1N=C(N)S/C1=C/C2=CC=C(O)C=C2

Molecular Formula

C10H8N2O2S

Molecular Weight

220.25

Precautions

H315, H319, H335

References & Citations

[1]Dupré A, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008;4 (2) :119-125.|[2]Ying S, et al. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72 (11) :2814-2821.