Zampilimab
Zampilimab (UCB-7858) is a monoclonal antibody against transglutaminase 2 (TG2) . Zampilimab inhibits TG2 crosslinking transamidation activity with an IC50 of 0.25 nM and a Kd of [1][2][3].
Product Specifications
CAS Number
2098280-42-1
Product Name Alternative
UCB-7858
UNSPSC
12352203
Target
Glutaminase
Type
Inhibitory Antibodies
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/zampilimab.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
[Zampilimab]
Molecular Weight
(143.48 kDa)
References & Citations
[1]Tempest R, et al. The Biological and Biomechanical Role of Transglutaminase-2 in the Tumour Microenvironment. Cancers (Basel) . 2021 Jun 3;13 (11) :2788.|[2]Prat-Duran J, et al. Transglutaminase 2 as a novel target in chronic kidney disease - Methods, mechanisms and pharmacological inhibition. Pharmacol Ther. 2021 Jun;222:107787. |[3]Huang L, et al. The effect of TG2-inhibitory monoclonal antibody zampilimab on tissue fibrosis in human in vitro and primate in vivo models of chronic kidney disease. PLoS One. 2024 May 16;19 (5) :e0298864.
Shipping Conditions
Dry Ice
Storage Conditions
Store at -80°C for 2 years
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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