IMPDH-IN-1
IMPDH-IN-1 (compound 44) is a bacterial inosine 5'-monophosphate dehydrogenase (IMPDH) inhibitor. IMPDH-IN-1 specifically binds to the catalytic domain of IMPDH. IMPDH-IN-1 potently inhibits the IMPDH of Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli[1].
Product Specifications
CAS Number
[3094970-14-3]
UNSPSC
12352211
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/impdh-in-1.html
Smiles
O=C(NC1=CC=C(Cl)C([N+]([O-])=O)=C1)NC(C)(C2=CC=CC(C3=CNC=N3)=C2)C
Molecular Formula
C19H18ClN5O3
Molecular Weight
399.83
References & Citations
[1]Nour Ayoub, et al. Synthesis, evaluation and mechanistic insights of novel IMPDH inhibitors targeting ESKAPEE bacteria. Eur J Med Chem. 2024 Sep 27:280:116920.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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