β-Glycerophosphate (disodium salt hydrate)

β-Glycerophosphate disodium salt pentahydrate is a bioactive endogenous metabolite and a phosphatase inhibitor. β-Glycerophosphate disodium salt pentahydrate plays an important role in inducing and maintaining osteoblast differentiation, mineral metabolism and signal transduction, and can be used as a drug carrier to form heat-sensitive hydrogels. β-Glycerophosphate disodium salt hydrate accelerates the calcification of vascular smooth muscle cells[1][2][3].

Product Specifications

CAS Number

[154804-51-0]

UNSPSC

12352211

Hazard Statement

H319

Target

Endogenous Metabolite; ERK; Phosphatase

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glycerophosphoric-acid-disodium-salt-hydrate.html

Purity

99.85

Solubility

H2O : 175 mg/mL (ultrasonic)

Smiles

OCC(OP(O[Na])(O[Na])=O)CO.[H]O[H].[x]

Molecular Formula

C3H7O6PNa2.xH2O

Precautions

H319

References & Citations

[1]Belfield A, et al. Inhibition of the nucleotidase effect of alkaline phosphatase by beta-glycerophosphate. Nature. 1968 Jul 6;219 (5149) :73-5.|[2]Shioi A, et al. Beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 1995 Nov;15 (11) :2003-9.|[3]Langenbach F, et al. Effects of dexamethasone, ascorbic acid and β-glycerophosphate on the osteogenic differentiation of stem cells in vitro. Stem Cell Res Ther. 2013;4 (5) :117.