Epsilon- (gamma-glutamyl) -lysine (TFA)

Epsilon- (gamma-glutamyl) -lysine (H-Glu (H-Lys-OH) -OH) TFA is an N (6) -acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon- (gamma-glutamyl) lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration[1].

Product Specifications

Product Name Alternative

H-Glu (H-Lys-OH) -OH (TFA) ; γ-Glu-ε-Lys (TFA)

UNSPSC

12352209

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/epsilon-gamma-glutamyl-lysine-tfa.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC([C@@H](N)CCC(NCCCC[C@H](N)C(O)=O)=O)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

Molecular Formula

C15H23F6N3O9

Molecular Weight

503.35

References & Citations

[1]Siegfried G Priglinger, et al. Potential Role of Tissue Transglutaminase in Glaucoma Filtering Surgery. Invest Ophthalmol Vis Sci. 2006 Sep;47 (9) :3835-45. |[2]A M El Nahas, et al. Elevated Epsilon- (Gamma-Glutamyl) lysine in Human Diabetic Nephropathy Results From Increased Expression and Cellular Release of Tissue Transglutaminase.Nephron Clin Pract. 2004;97 (3) :c108-17.