Pitolisant (hydrochloride)

Pitolisant hydrochloride is a potent and selective nonimidazole inverse agonist at the recombinant human histamine H3 receptor (Ki=0.16 nM) .

Product Specifications

CAS Number

[903576-44-3]

Product Name Alternative

Ciproxidine; BF 2649

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/Pitolisant-hydrochloride.html

Concentration

10mM

Purity

99.92

Solubility

DMSO : ≥ 43 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

ClC(C=C1)=CC=C1CCCOCCCN2CCCCC2.Cl

Molecular Formula

C17H27Cl2NO

Molecular Weight

332.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Ligneau X, et al. BF2.649 [1-{3-[3- (4-Chlorophenyl) propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther. 2007 Jan;320 (1) :365-75.|[2]Dudek M, et al. H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by LY170053 in mice. Metab Brain Dis. 2016 Oct;31 (5) :1023-9.|[3]Uguen M, et al. Preclinical evaluation of the abuse potential of Pitolisant, a histamine H? receptor inverse agonist/antagonist compared with CRL 40476. Br J Pharmacol. 2013 Jun;169 (3) :632-44.