GPX4-IN-6

GPX4-IN-6 (Compound C25) is a GPX4 covalent inhibitor with an IC50 value of 0.13 μM. GPX4-IN-6 (Compound C25) can induce ferroptosis for the research of triple-negative breast cancer (TNBC) [1].

Product Specifications

CAS Number

[2922824-07-3]

UNSPSC

12352005

Target

Ferroptosis; Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gpx4-in-6.html

Concentration

10mM

Purity

99.65

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(CBr)N(C1=CC(OC)=C(F)C(OC)=C1)C2=CC(OCCO3)=C3C=C2

Molecular Formula

C18H17BrFNO5

Molecular Weight

426.23

References & Citations

[1]Chen T, et al. Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66 (14) :10036-10059.