MS39N

MS39N (compound 27) is a negative control for MS39 that binds EGFR without inducing degradation[1].

Product Specifications

CAS Number

[2675490-96-5]

UNSPSC

12352005

Target

EGFR

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ms39n.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

COC(C(OCCCN1CCN(CC1)C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N2[C@H](C[C@@H](C2)O)C(NCC3=CC=C(C4=C(C)N=CS4)C=C3)=O)=O)=O)=O)=C5)=CC6=C5C(NC7=CC(Cl)=C(C=C7)F)=NC=N6

Molecular Formula

C55H71ClFN9O7S

Molecular Weight

1056.72

References & Citations

[1]Discovery of Potent and Selective Epidermal Growth Factor Receptor (EGFR) Bifunctional Small-molecule Degraders. J Med Chem. 2020 Feb 13;63 (3) :1216-1232.