TM2-115
TM2-115 inhibits malaria parasite histone methyltransferases, resulting in rapid and irreversible parasite death[1].
Product Specifications
CAS Number
1197196-47-6
UNSPSC
12352005
Target
Histone Methyltransferase; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/tm2-115.html
Purity
98.37
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CCC(NC2=C3C=C(OC)C(OCC4=CC=CC=C4)=CC3=NC(N5CCN(C)CCC5)=N2)CC1
Molecular Formula
C28H38N6O2
Molecular Weight
490.64
References & Citations
[1]Malmquist NA, et al. Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2012 Oct 9;109 (41) :16708-13.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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